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methylmalonate  (MedChemExpress)
94
MedChemExpress methylmalonate
ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of <t>methylmalonate</t> (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
Methylmalonate, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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13c4 methylmalonic acid  (Millipore)
90
Millipore 13c4 methylmalonic acid
ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of <t>methylmalonate</t> (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
13c4 Methylmalonic Acid, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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methylmalonic aciduria with homocystinuria  (5 PRIME)
90
5 PRIME methylmalonic aciduria with homocystinuria
ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of <t>methylmalonate</t> (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
Methylmalonic Aciduria With Homocystinuria, supplied by 5 PRIME, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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d4902 methylmalonate medchemexpress  (MedChemExpress)
94
MedChemExpress d4902 methylmalonate medchemexpress
ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of <t>methylmalonate</t> (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
D4902 Methylmalonate Medchemexpress, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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bis[(12-crown-4)methyl]-2-dodecyl-2-methylmalonate 1  (Dojindo Labs)
90
Dojindo Labs bis[(12-crown-4)methyl]-2-dodecyl-2-methylmalonate 1
ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of <t>methylmalonate</t> (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
Bis[(12 Crown 4)Methyl] 2 Dodecyl 2 Methylmalonate 1, supplied by Dojindo Labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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methylmalonic acid elisa kit  (Abbexa Ltd)
90
Abbexa Ltd methylmalonic acid elisa kit
ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of <t>methylmalonate</t> (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
Methylmalonic Acid Elisa Kit, supplied by Abbexa Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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methylmalonic acid thermofisher  (Thermo Fisher)
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Thermo Fisher methylmalonic acid thermofisher

Methylmalonic Acid Thermofisher, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pan methylmalonic acid  (Cell Signaling Technology Inc)
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Cell Signaling Technology Inc pan methylmalonic acid

Pan Methylmalonic Acid, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mma  (MedChemExpress)
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MedChemExpress mma

Mma, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of methylmalonate (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .

Journal: Cell Genomics

Article Title: An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis

doi: 10.1016/j.xgen.2025.100855

Figure Lengend Snippet: ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of methylmalonate (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .

Article Snippet: Methylmalonate , MedChemExpress , Cat# 516-05-2.

Techniques: Control, Over Expression, CRISPR, Knock-Out, Labeling, Flux Assay, Two Tailed Test

Journal: iScience

Article Title: Forced intracellular degradation of xenoantigens as a modality for cell-based cancer immunotherapy

doi: 10.1016/j.isci.2025.111957

Figure Lengend Snippet:

Article Snippet: Methylmalonic acid (MMA) , ThermoFisher , Cat#: 127090050.

Techniques: Recombinant, Synthesized, Selection, Enzyme-linked Immunosorbent Assay, Mass Spectrometry, Software